The In Vitro Serum Protein-Binding Characteristics of Bis-(2-Ethylhexyl) Phthalate and Its Principal Metabolite, Mono-(2-Ethylhexyl) Phthalate
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چکیده
منابع مشابه
The in vitro serum protein-binding characteristics of bis-(2-ethylhexyl) phthalate and its principal metabolite, mono-(2-ethylhexyl) phthalate.
The metabolism and toxicity of the ubiquitous plasticizer, bis-(2-ethylhexyl) phthalate (DEHP), and its principal metabolite, mono-(2-ethylhexyl) phthalate (MEHP), have been extensively investigated. In an attempt to understand their disposition in man, we studied the in vitro serum protein-binding characteristics of these compounds, using ultracentrifugation and agarose gel electrophoresis. Th...
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The adsorption of Bis (2-ethylhexyl) phthalate (DEHP) on the carbon adsorbents (Chezacarb S and Chezacarb SH) and polymer adsorbent on basis of polypropylene with polyethylene (Reo Fb) was studied. Efficiency of DEHP adsorption (concentration DEHP to 10 g.L, concentration of the adsorbents 1.7 g.L) was more then 99.9 %. By the sample from groundwater was efficiency more as 99.7 % in the case of...
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The present study applies a chemical activity-based approach to: 1) evaluate environmental concentrations of di-ethylhexyl phthalate (DEHP; n = 23 651) and its metabolite mono-ethylhexyl phthalate (MEHP; n = 1232) in 16 environmental media from 1174 studies in the United States, Canada, Europe, and Asia, and in vivo toxicity data from 934 studies in 20 species, as well as in vitro biological ac...
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Mono(2-ethylhexyl) phthalate (MEHP), one of the main metabolites of di(2-ethylhexyl) phthalate (DEHP), exerted embryo/fetotoxic effects similar to those of DEHP at lower doses. Oral administration of MEHP (1 mL/kg) to the mice of 8 days gestation resulted in less than 32% of live fetuses, all of which were deformed. When DEHP (10 mL/kg) was given to the pregnant mice of 8 days gestation, approx...
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We report a radioimmunoassay for mono-(2-ethylhexyl) phthalate that has been coupled to a protein carrier as a radioligand. Competitive interference tests with a variety of related compounds indicated the assay to be highly specific. Quantitative comparison of mono-(2-ethylhexyl) phthalate values in plasma and serum samples between the radioimmunoassay and gas chromatographic procedures indicat...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1988
ISSN: 0091-6765
DOI: 10.2307/3430640